Heroin to Parkinson: the case of MPTP and the Frozen Addicts - League fresnels Nerd
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The Second World War, albeit at a high price, had given a boost to medicine: penicillin, blood transfusions, tetanus and malaria, and methadone. After the conflict ended, the biomedical research continue, even those on painkillers.
We are in 1947, in the laboratories of Hoffman-La-Roche, fresnels the two chemicals Albert Ziering fresnels and John Lee are at work between flasks, cylinders and sling in an attempt to produce an analogue of morphine, as effective in pain relief, but not in creating fresnels dependence.
The enthusiasm of our attempt is quickly damped: unfortunately the new drug is not that just another form of Mepiridina (commercially Demerol), and presents it as effective fresnels as the same side effects. After publishing the results of a specialized journal, the project is closed and forgotten.
Years pass, and the wars continue. Ends Vietnam: one of the toughest wars for US soldiers, who sees a massive spread of drugs to withstand fresnels the wear and tear of the front. fresnels Of the survivors, 15% are addicted to heroin, and with their return this takes powerfully foot on the streets.
And it is then, in Maryland in 1976, that a young and enterprising chemistry student, aka Barry Kidston, fresnels decides to exploit his studies trying to give the market what he asked, but at the same time covering their backs: a drug for recreational use, but legal.
The MPPP is a molecule from other Demerol, which the FDA has never interested: then synthesize it could provide him with an opiate effects of the first (high demand on the roads), but not its legal restrictions. What can go wrong? He is young, is a chemical, and fate seems to be favorable. Barry Kidston. Compresreste drug from him?
Barry then sets up a small workshop in the basement of her parents' house, and we can imagine him there, intent to synthesize successfully its MPPP and get high with the fruits of his hard work while the radio pass Led Zeppelin, Queen, and Iron Maiden. Everything is going well. For some months.
But one day, shortly after starting a new bench, Barry begins to feel strange. The movements are becoming slower and more difficult, until no longer able either to move or to speak: Barry is petrified.
Is hospitalized, and since Asclepius not considered sufficient punishment to his hubris, he was diagnosed with catatonic schizophrenia, and is then subjected to a classical electroconvulsive therapy routine. For long months. In the end, however, the diagnosis is correct: Parkinson's disease.
Barry can speak again, crying and tells everything to doctors: now a task force of 'NIMH (National Institute of Mental Health, a branch of' NIH) swoops in its factory and takes samples of his last game.
The analyzes reveal that the 'MPPP is not pure, but has in fact also significant traces of a similar substance, the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, or MPTP, an impurity that is created at a temperature above 30 C in the synthesis process. Easy summer.
Dr. Davis, who has followed this strange patient, it performs the autopsy and detects a loss of dopaminergic neurons of the substantia nigra, confirming the diagnosis of Parkinson's. The substantia nigra owes its name to the pigmentation of dopaminergic neurons: their death leads to a sb
Select Areas Purchasing Clothing Accessories Previews Gadgets Reviews Unboxing Creativity Architecture fresnels Furniture fresnels Bullshit Photography Graphics & Design Ideas Illustration Infographic Advertising Video Culture Archaeology Art Kitchen Documentaries Philosophy Geography Guide Psychology School & University History Entertainment Animation Anime & Manga Movies Cosplay Pussy Comics Books Music Television Theater Youtube Games Action Figures Boardgames Card Games Role Model Toys Videogames Emulation Retrogaming Wargames News Real Life Current Job Politics Religion Sport Sciences Aeronautics Astronomy Physics Chemistry Economics Mathematics Mechanical Engineering Medicine Nature Technologies Audio Car & Motorcycle Hardware fresnels eReaders fresnels Internet Mobile AndroidLand iPhone / iPad Windows Phone Retrocomputing Robotics Software Hacking & Cracking Linux Mac / OS X Opensource Programming Windows Tourism Africa America Asia Europe Oceania Italy Japan Russia USA Headings Amarcord Bloodbath bonsaikitten Comics Cool Story Bro Curiosity Space Lego History Book Club Nerdeconomy Motorsport Facts Nerd Nerd Nerd Quest Popcorn Startup Stories Viral Now Web Series TV Nerdvana Nerd Play Bricknauts Youtube Channel Events Reviews Shop Merchandising unwary Purchases Cool Story Book
Technologies
Save on Pocket
The Second World War, albeit at a high price, had given a boost to medicine: penicillin, blood transfusions, tetanus and malaria, and methadone. After the conflict ended, the biomedical research continue, even those on painkillers.
We are in 1947, in the laboratories of Hoffman-La-Roche, fresnels the two chemicals Albert Ziering fresnels and John Lee are at work between flasks, cylinders and sling in an attempt to produce an analogue of morphine, as effective in pain relief, but not in creating fresnels dependence.
The enthusiasm of our attempt is quickly damped: unfortunately the new drug is not that just another form of Mepiridina (commercially Demerol), and presents it as effective fresnels as the same side effects. After publishing the results of a specialized journal, the project is closed and forgotten.
Years pass, and the wars continue. Ends Vietnam: one of the toughest wars for US soldiers, who sees a massive spread of drugs to withstand fresnels the wear and tear of the front. fresnels Of the survivors, 15% are addicted to heroin, and with their return this takes powerfully foot on the streets.
And it is then, in Maryland in 1976, that a young and enterprising chemistry student, aka Barry Kidston, fresnels decides to exploit his studies trying to give the market what he asked, but at the same time covering their backs: a drug for recreational use, but legal.
The MPPP is a molecule from other Demerol, which the FDA has never interested: then synthesize it could provide him with an opiate effects of the first (high demand on the roads), but not its legal restrictions. What can go wrong? He is young, is a chemical, and fate seems to be favorable. Barry Kidston. Compresreste drug from him?
Barry then sets up a small workshop in the basement of her parents' house, and we can imagine him there, intent to synthesize successfully its MPPP and get high with the fruits of his hard work while the radio pass Led Zeppelin, Queen, and Iron Maiden. Everything is going well. For some months.
But one day, shortly after starting a new bench, Barry begins to feel strange. The movements are becoming slower and more difficult, until no longer able either to move or to speak: Barry is petrified.
Is hospitalized, and since Asclepius not considered sufficient punishment to his hubris, he was diagnosed with catatonic schizophrenia, and is then subjected to a classical electroconvulsive therapy routine. For long months. In the end, however, the diagnosis is correct: Parkinson's disease.
Barry can speak again, crying and tells everything to doctors: now a task force of 'NIMH (National Institute of Mental Health, a branch of' NIH) swoops in its factory and takes samples of his last game.
The analyzes reveal that the 'MPPP is not pure, but has in fact also significant traces of a similar substance, the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, or MPTP, an impurity that is created at a temperature above 30 C in the synthesis process. Easy summer.
Dr. Davis, who has followed this strange patient, it performs the autopsy and detects a loss of dopaminergic neurons of the substantia nigra, confirming the diagnosis of Parkinson's. The substantia nigra owes its name to the pigmentation of dopaminergic neurons: their death leads to a sb
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